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1 1Department of Obstetrics and Gynaecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin University Hospital, Martin, Slovak Republic. 2 2Division of Oncology, Biomedical Center Martin, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic. 3 3Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovakia.
Mark Zubor - Stats, Game Logs, Splits, and much more.
4 4Department of Psychiatry and Clinical Psychology, Faculty of Medical Science, Goce Delcev University, Stip, Macedonia. 5 Department of Obstetrics and Gynaecology, Kukuras Michalovce Hospital, Michalovce, Slovakia. 6 Oncogynecology Unit, Penta Hospitals International, Svet Zdravia, Michalovce, Slovakia. 7 7Centre for Obstetrics and Gynaecology, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany. 8 8Breast Cancer Research Centre, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany. 9 9Centre for Integrated Oncology, Cologne-Bonn, Rheinische Friedrich-Wilhelms-University of Bonn, Bonn, Germany.
Malignancies are one of the leading causes of mortality in women during their reproductive life. Treatment of gynecological malignant tumors during pregnancy is possible but not simple, since it creates a conflict between care of the mother and the fetus. BC is the most prevalent malignancy diagnosed in pregnancy, ranking up to 21% of all pregnancy-related malignancies. Due to its stets increasing prevalence, aggressive cancer subtype, and severe ethical and psychological aspects linked to the disease, experts raise an alarm for an acute necessity to improve the overall management of the PABC-the issue which has strongly motivated our current paper. Comprehensive research data and clinical experience accumulated in recent years have advanced our understanding of the disease complexity. PABC treatment must be individualized with an emphasis on optimal care of the mother, while observing standard treatment protocols with regard to safety of the fetus.
Treatment protocols should be elaborated based on the individualized patient profile, bearing in mind the acute danger to the mother, maximizing the therapy efficacy and minimizing harmful effects to the fetus. Complex consulting on treatment options, their impacts on pregnancy and potential teratogenic effects requires tight 'doctor-patient' collaboration. Complications that may arise due to the treatment of breast cancer in pregnancy require a multiprofessional expertise including oncologists, neonatologists, perinatologists, obstetricians, teratologists, and toxicologists, and an extensive psychological support throughout the pregnancy and after giving birth.
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Thereby, specifically psychological aspects of PABC diagnosis and follow-up are frequently neglected, being not yet adequately explored in the entire disease management approach. Herewith, we update the status quo regarding the currently available diagnostic modalities, complex treatment algorithms, and novel clinical approaches which altogether argue for an urgent necessity of a paradigm shift moving away from reactive to predictive, preventive, and personalized medical approach in the overall management of PABC meeting the needs of young populations, persons at high risk, affected patients, and families as the society at large. The histopathological diagnosis of pregnancy-associated breast cancer by core-needle biopsy. Core-needle biopsy is the gold standard method for breast cancer histological examination. This method is outpatient procedure, well tolerated, and quick.
If compared to other biopsy techniques, this method provides significantly better interpretation and tissue characterization than fine-needle aspiration and allows specifying the definitive histopathological diagnosis of PABC. As it is less invasive than vacuum-assisted biopsy or surgical/core biopsy, also the risks associated with this procedure is lower.
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